What is organ-on-a-chip technology?

foreign [Music] Technologies organometer chip Technologies also known as microphysiological systems allow researchers to culture physiologically relevant combinations of primary human cells together in a microfluidic chip within the chip scaffolds coated in extracellular Matrix encourage cells to form human organ or tissue replicas by providing an environment that mimics the body different tissue types can be grown each recreating the specific function mechanics and physiological responses of th

at organ microfluidics circulate media through these structures to mimic blood flow providing nutrients oxygen and biomechanical cues that can keep the culture alive for multiple weeks oocs can be dosed once or multiple times to flag acute and chronic drug toxicity and can be turned into disease models to identify druggable targets or to predict drug efficacy predictive human organ models can be used in isolation or they can be interconnected to form systems that facilitate crosstalk these multi

-organ models provide a way to predict the effects the body might have on a Drug's absorption metabolism or bioavailability they can also be used to understand interactions between organs such as inflammation which Drive disease and cause unexpected toxicities now that we've established what they are why are ooc Technologies important drug Discovery is changing pipelines are not just made up of small molecule Therapeutics anymore they also include human specific therapies like oligonucleotides a

nd RNA protein degraders Next Generation peptides antibodies and antibody drug conjugates and cell and Gene Therapies these drug types have human specific targets require Advanced delivery techniques and have a complex mechanism of action traditional testing methods like 2D cell culture and animal models have limitations that are exacerbated by this new wave of drug types 2D cell culture methods fail to adequately recreate the physiological complexities of human organs tissues and immune systems

animal models overcome these limitations but lack human relevance ooc Technologies provide a path forward for drug development Bridging the Gap between animal and cell models by enabling the simulation of human biological conditions by providing more reliable predictions of drug effects ooc Technologies can help to develop safe and efficacious Therapeutics faster and more cost effectively so what's in store for the future of ooc technology both researchers and ooc Tool providers are working wit

h the aim to recreate more human organs with these models until it is possible to link them together and simulate a body on a chip this will allow sex or genetic differences to be further understood and a patient's own cells can be used to support the development of more personalized medicines if you want to learn more about integrating ooc into your research then check out our in focus with cnbio at www.biotechnics.com foreign