Drug Trial Goes Horribly Wrong as Participants Die If They Fall Asleep

Secretly in the labs of Blackwood Pharmaceuticals,  a mouse is retrieved from its cage to be decapitated. Meanwhile Claire arrives at the  company’s very modern facilities to participate in some clinical trials for five days because she  needs the money. Once everyone has changed into scrubs, they’re called to the Exam Room, where  they discover they have no wi-fi or reception. Claire is trying to tell her worried mom not to  contact her anymore, but the message doesn’t go through. It seems the

two of them were in some  sort of fight. Then the group meets Doctor Burke, who will supervise the trial. The medicine dosage  will start low and go up each day, and during those five days participants won’t be allowed  to leave that floor. During the rest of the day, a nurse keeps checking on their health, repeating  the same questions about any possible pain, checking their pulse, taking blood samples,  and even following them into the bathroom to take samples there too. When Alison tries to 

befriend Claire, she snaps and yells at her, only to interrupt herself when she suddenly  needs to throw up. After puking in the bathroom, Claire bumps into Amir and learns he’s a med  student, who hopes to get an internship with the company in the future. That night, Claire’s  brain keeps having a strange chemical reaction, and she can’t sleep. When she leaves her room,  she discovers all the others can’t sleep either, which worries them. Marcus says he’s feeling  something he can’t describe. T

he next morning, Burke tells them that a bit of insomnia isn’t a  big deal and the process of dozens of tests starts again. On the wall, a clock counts down the hours  left for the trial to end. Later in her office, Burke calls her superiors to inform them that  whatever is that she’s testing is going directly into the participants’ central nervous system and  causing serious brain inflammation. The higher-ups remind her this is a double-blind trial, meaning  she isn’t allowed to have any more i

nformation. However they’re shocked to hear that the test  results Burke sent them happened in just one day, which it’s too fast. The next day, Burke informs  the group that the parameters of the trial have changed and now the company wants to know how long  the group can stay awake. They are forbidden from trying to sleep and if they feel too tired they  must inform Burke or a nurse. After Claire takes the new dose, she’s put in an MRI machine,  which makes her very anxious because she’s claust

rophobic. The darkness and the weird  noises bring back horrible memories of her drunk mom telling her off and refusing to let her  out. Terrified, Claire begs for the test to stop, but it keeps going until the end. Time continues  to pass and the group gets more and more concerned about the lack of sleep, not to mention how high  the medicine dose is getting. Burke reminds them they’re free to leave at any point but also  announces that every person who stays until the end will get a bonus of t

hirty thousand euros.  Most of the group loves the idea and starts cheering, but Claire and Amir are still wary,  believing there’s always a catch. The group starts playing music and drinking champagne to celebrate,  and Alison convinces Claire to dance with her. However Claire starts to yawn multiple times in a  row, so she leaves to inform Burke. Then Ray yawns as well, so Burke interrupts the celebrations  and sends everyone to drink water. Afterward Burke calls her superiors again, explainin

g  the participants’ immune systems have gone haywire. She wants to end the trial early, but the  higher-ups refuse and order her to keep upping the dose. Meanwhile the participants are keeping each  other awake by chatting, however Claire starts to doze off. Alison immediately snaps her out of  it and asks her about her plans for the money, but Claire is very dismissive and hurts her  feelings, so Alison leaves the room. Since the moment was ruined, Amir leaves as well and as  he takes the corr

idor, he overhears Burke tell her bosses she refuses to take responsibility  for whatever happens next. After she leaves her office, Amir sneaks inside and looks at the  test results on her computer, discovering the brain inflammation. Horrified, he copies all the  files in a flash drive. Back to the group, they’re watching TV when the screen suddenly starts  failing. Claire notices Alison sitting on her own and approaches her to apologize, only to discover  she’s fallen asleep. At that moment A

lison starts bleeding from her eyes, nose, and ears, then she  has a seizure. Her body falls to the floor and her eyes become bloodshot as she pukes, and after  lots of shaking, she dies. When Burke sees this, the facility’s computer announces that there has  been a security breach and from now on they’ll be under lockdown protocol. An alarm starts ringing  through every room and the lights turn red as the computer starts the countdown, so Burke and the  participants immediately run away. The do

or is already closing, but Burke tries to cross anyway,  causing her to get stuck and severely hurt by the heavy metal. The group drags her out, but it’s  too late: Burke apologizes and dies while the door closes, leaving the participants stuck inside.  The clock on the wall resets and now counts twenty-four hours before the lockdown ends. Amir  comes out of Burke’s office and tells everyone to stay awake because if they fall asleep, they’ll  die. He explains he saw the tests and that for the la

st four days, their brains have been pushed into  overdrive, so now they’re shutting down. Everyone panics and Ray even gets a bit aggressive while  the others try to push the door to no avail. In the rec room, the television plays a message from  the company asking them to be patient. Next they look around and find a bunch of smelling salts,  so each of them gets five packets that should last all night. Amir warns them to use them at the  last second, but Ray immediately uses one anyway. Then R

ay finds some medicine in a cabinet, but  Amir immediately warns them against it. In fact, he advises not to drink coffee either. Any kind  of stimulant will just make the metaphoric flames in their brains burn faster. Amir is sure this  is treatable, so they need to wait for the doors to open and find help. For the next few hours,  the group tries their best to stay awake. By now they’ve been awake for one hundred hours. Amir  thinks that the brain inflammation will go down now that they don’t

take the medicine anymore,  but when he scans Claire’s brain for a checkup, the results terrify him. However he doesn’t tell  the others. As Claire walks down the corridor, she feels incredibly dizzy and begins hearing her  mother’s voice. She decides to record a message for her mother, who is under palliative care in  the hospital because her liver was ruined by all the drinking. However Claire ends up deleting the  video. Afterward she finds the mice in the lab and decides to free them, but th

ey refuse to go away.  With sixteen hours to go, the group starts having trouble staying awake. Ray slaps his cheek to get  rid of the drowsiness because he’s already used all his salts and soon he starts bothering the  others, asking them to share theirs but nobody wants to help him. Meanwhile Amir continues to  run tests in the Exam Room with the two bodies, and suddenly Burke sits up behind him.  However when Amir turns around, she’s still down and dead, which means he’s starting  to experien

ce hallucinations. In the rec room, Claire stares at the wall while she continues to  hear her mother’s voice. Darkness takes over her vision as she remembers her creepy childhood room,  but before she gives in, Marcus snaps her out of it. Claire can’t understand how Marcus is doing  so well, so he shows her a scar on his leg that he got during a serious hiking accident, saying  the body will always push through when it needs to survive. Afterward Claire goes to Burke’s office  and looks at the

brain scans before checking her patient file. She discovers notes that talk about  the destructive behavior and despair in her life, which made her a perfect candidate for high-risk  trials. Later Claire finds Vanessa using fire to stay awake, saying she refuses to give up. In  the bathroom, Marcus is whistling and hears someone whistle back although he’s supposed to be  alone. Then he turns on the tap, only to discover the water doesn’t make noise when it falls. It  isn’t until he turns it off

that he finally hears the delayed noise. When he knocks on the mirror,  the same happens: the sound arrives a few seconds later. Scared, Marcus leaves the bathroom  and hears the whistling in the corridors. He starts wandering around yet doesn’t see a single  person, and when he makes it to the front hall, he’s shocked to see the door opening. Marcus  goes through the door and into a deep darkness, and a moment later the others find him dead  on the floor because the hallucination made him fall

asleep. There are still fifteen hours  to go, so everyone worries. Claire feels dizzy and has a vision of Alison waking up, so she walks  away from the group rather clumsily. She makes it to the kitchen and after seeing a mouse staring  at her, she uses fire to reanimate her body. The resulting burn scar is awful, but Claire feels  awake and alert now. After bandaging her hand, she finds the others and yells at them, announcing  she’s tired of waiting and that she’ll find a way out. The group ma

kes a map of the facility to  learn what wall they need to break to get out. Amir tells them it won’t work because facilities  like this one are built with tight security, but the others ignore him and start hitting  the wall with an axe. By taking turns, they manage to work quite fast and eventually the  hole is big enough to find the end. Unfortunately Amir was right: the wall is protected by metal  as thick as the door. While Claire goes looking for Amir to ask for more ideas, Ray starts to 

wonder how Amir knew about the metal wall and concludes he must be secretly working for the  company. When Claire finds Amir, he gives her a letter with a confession while hallucinating  Burke’s dead face. It turns out it was his copying the files that triggered the lockdown,  and now he feels so guilty that he decides to fall asleep. Claire immediately stops him and  keeps throwing fire metaphors to understand what they can do with their brains. This gives  Amir an idea: using certain medicines

as poison, he can create an effect that usually would cause  brain death, but with these side effects they’re having it should stop their death instead.  Ignoring the hallucinations, Amir immediately starts to work on the mix. Claire rushes to tell  the others and bumps into Paul, who tells her not to trust Amir. He reveals he searched Amir’s  things and found the bottle of stimulants he told them not to take, which is now empty. At  that moment the power goes out, so they use their phone flash

lights to move around. Claire starts  hearing her mom’s and Alison’s voices and starts having a breakdown before turning around to find  a dead Alison standing in front of her. Screaming, Claire drops her phone and the light goes off so  she tries using a lighter instead, causing her to see more dead faces in the dark. When she finally  gets a flame going, the hallucinations stop and she finally finds the electricity box, allowing  her to bring power back. Then she finds Paul on the ground and w

akes him up before he could die.  Afterward the group confronts Amir, asking him about the stimulants and the power box. He swears  he poured them out for safety and that he didn’t mess with the power, but Ray punches him for it  and ties him up with Paul’s help. Vannesa, Ray, and Paul are sure he's hiding something and ignore  Claire’s concerns as they decide they have to make Amir confess through any means. Ray gets ready to  hurt Amir with a knife to make him talk, so Claire stops him by conf

essing Amir has been working on  a cure. When Ray says that Amir's plan is to kill them, Claire volunteers to be the first subject  to test it, that way they’ll know if it’s safe or not. The group still refuses to release Amir  though, so he gives them instructions on how to mix the medicine. While Paul works, Vanessa talks  to Ray in private, confessing she saw him trip the fuse. Ray admits he was trying to make Amir  fall asleep to prove he was faking it, so Vanessa shares one more secret: she

’s found a sedative  they can use. At that moment, Paul finishes mixing the cure and gets the injection ready. While  everyone is distracted, Vanessa approaches Amir to give him the sedative, however she suddenly  falls to the floor. In an out-of-body experience, Vanessa watches the others rush to her body, but  soon smoke and darkness surround her. She sees the devil appear before her and screams as her  real body starts bleeding and having a seizure. Paul rushes to grab the cure, but Vanessa’s

  shaking knocks the needle away and breaks it, then she pukes and finally dies. To make matters  worse, Paul’s fast movement knocks the jar with the rest of the cure off the table, causing it to  break as well. Amir starts laughing like a maniac, causing Claire to snap and threaten him with  a knife. When she realizes she’s losing it, she leaves the room to check on the clock, but her  blurry vision makes her see “good night” instead of numbers. Then she starts staring at the wall  as she hears

her mom’s voice again and darkness takes over her mind. A dizzy Claire takes out her  phone and records a message for her mother before finding her last salt packet, but she falls to the  floor and drops it. Suddenly her body floats up as heavenly music starts playing, however Claire  fights against the hallucination and swims in the air to reach the packet, finally taking the salts  to wake up. Then she hears a noise and taps on the rec room wall to discover it’s hollow. With  Paul’s help, she

breaks down the wallpaper and finds a hidden autopsy room. There’s a door at the  back that takes her to a corridor and an elevator, meaning they can finally get out. Claire wants  to tell the others, but Paul says they should leave alone. Meanwhile Amir keeps seeing Burke,  who insists he should stand up for himself and points out that Claire left the knife nearby. In  the bedroom, Ray says goodbye to Vanessa's body, only to find Amir’s letter in her pocket. Furious,  Ray goes to find Amir, wh

o immediately starts screaming for help. Claire hears him and runs  back, so Paul has no choice but to go with her. In the lab, Ray grabs a scalpel and gets ready  to get revenge on Amir, who struggles against the fabric on his wrist and manages to break them.  He jumps on Ray and stabs him with the scalpel, but then the sickness finally makes him lose  it and he grabs the knife to stab Ray multiple times until he’s dead. At that moment Claire  and Paul arrive and try to calm him down, but Burke

’s hallucination pushes Amir into  finishing the job. The duo immediately runs away, and Paul hides in the rec room, locking the door  behind him. Now Claire has to keep running into the MRI room, where Amir catches up and throws  her around, accidentally turning on the machine. When Amir is about to stab Claire, the magnets in  the MRI machine take the knife away from his hand, so Claire kicks Amir and runs away. Meanwhile  Paul makes it to the elevator and activates it, but unfortunately this

isn’t an elevator,  it’s an incinerator. Soon huge flames come out of the walls and burn Paul to death. Back to  Claire, she finds some scissors and gets ready to defend herself while Amir retrieves his knife  and goes after her. Both of them are about to fall asleep when suddenly the clock hits zero and  the computer announces lockdown is over. Lights return and the door opens to let in a few armed  men who immediately killed Amir. Claire hears the gunshot and rushes to hide while the men searc

h  the floor to get all the bodies out. Once the coast is clear, Claire tries to escape and finds  the bodies in bags, so she quickly covers her face with Amir’s blood and gets inside a bag to pretend  to be dead. A man checks on her and believes his coworker found the body, so she’s thrown in the  back of a truck with the others. Claire uses her phone’s flashlight and keeps hallucinating  that a dead Alison is in the bag with her, so she closes her eyes and hums her mother’s  song. When she ope

ns her eyes again, a more friendly Alison smiles at her before disappearing.  Once the truck is far enough from the facility, Claire comes out of the bag, and seeing her in  the mirror gives the drivers such a shock that it causes the vehicle to crash. Claire sees both  men are down and immediately leaves the truck, only managing a few steps before falling  unconscious. Four months later, Claire is still in a coma in the hospital. A newscast  announces that Blackwood Pharmaceuticals was cleared

of any crimes and the incident was blamed  on Burke. At that moment, Claire opens her eyes.